How do I deal with diagnostic uncertainty in medicine?

You handle most admissions well now, but the not-knowing still sits on you. That is honest. Uncertainty is the hardest part of medicine because a person's wellbeing rides on it, and the body does not always tell you plainly what is wrong. Feeling that weight means you take the work seriously, which is exactly what you want in a doctor. Uncertainty is not a gap in your skill. It is the actual condition you work in. The best physicians are not the ones who are always certain; they are the ones who act wisely while unsure. You gather what you can, you weigh the likelihoods, you stay ready to change course as new facts arrive. That is not a failure to know. That is the skill itself. When a case is murky, name your leading answer and the next most likely one, and decide what would tell them apart. Turn the fog into a question you can pursue. You will not always be certain. You can always be careful.