How do I find meaning in research when most of it fails?

You work in a field where failure is not the exception but the daily weather, and you are asking what keeps that meaningful. That is the right question, and the fact that you are asking it is what will keep you going where others burn out. The meaning is not waiting at the end, in the cure you may or may not reach. It is in the work itself, done honestly, day after day, in service of something larger than any one result. Each careful experiment, even a failed one, is a brick laid in a wall you may never see finished. The cathedral gets built by people who never saw the roof. When a stretch of failures wears you down, shift your eye from the outcome to the contribution. Write down what one failed experiment actually taught, what it ruled out, what it clarified. Let that be a real win. Meaning built on outcomes is fragile here. Meaning built on faithful work will hold.